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KMID : 0617320080190010046
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Journal of Pharmacetical Sceiences Ewha Womans University
2008 Volume.19 No. 1 p.46 ~ p.57
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Scandium(Ⅲ) Triflate-Catalyzed Coumarin Synthesis
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Jung Keum-Nyeo
Park Yun-Jeong
Ryu Jae-Sang
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Abstract
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Scandium(Ⅲ) triflate is an excellent catalyst in the von Pechmann condensation. The solvent-free catalytic reactions proceed smoothly with a range of phenols and β-ketoesters in the presence of 10mol% scandium(Ⅲ) triflate at 80℃. This simple method affords various 4-substituted coumarins in good to excellent yield and is superior to the classical method in several aspects: solvent-free conditions, short reaction times, a decreased catalyst loading, a mild reaction temperature, and an easy workup.
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KEYWORD
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Coumarins, Pechmann reaction, Phenols, Sc(OTf)3, solvent-free
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